Controlo químico de bebidas adulteradas em crimes facilitados com drogas

  • J.A. Prior Professor Auxiliar, Requimte, Laboratório de Química Aplicada, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto. Portugal
  • D.S. Ribeiro Investigador Auxiliar, Requimte, Laboratório de Química Aplicada, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto. Portugal
  • J.L. Santos Professor Auxiliar, Requimte, Laboratório de Química Aplicada, Departamento de Ciências Químicas, Faculdade de Farmácia da Universidade do Porto. Portugal
Keywords: Drug facilitated crime, Automatic methodology, Spiked drinks, Drugs of abuse, Drug screening

Abstract

Although drugs are developed with therapeutics intentions, sometimes some substances are used for purposes other than those the pharmacologist had in mind. The word “drug” also involves psychoactive substances that can be used for medicinal or non-medicinal purposes in which it is included substances that are legal or illegal. The use of drugs for intentions other than their therapeutic purposes has become a growing public concern making their study very important from the toxicological standpoint. When alleged victims report that they were robbed or assaulted while incapacitated by a drug, toxicological chemical analysis is imperative to help substantiate the victim’s claim. These criminal offenses are known as drug facilitated crimes.

The branch of science dedicated to toxicology studies has two application fields, forensic and analytical toxicology, that are interdisciplinary and that comprise all the scientific facts related with crimes committed through the use of drugs. Most often, the cases of crimes facilitated by drugs involve substances that have strong central nervous system depressant effects that are availed to easily render victims to robberies or sexual assaults. As new drugs are continuously being synthetized and new methods are used for drugging victims without their knowledge or consent it is important to develop new analytical methods that can assist in the investigation for figuring out all the details about this sort of crimes or enable ways of their prevention. For example, one way of drugging victims without being aware of is through drink spiking in social entertainment places, during parties, raves, etc. In these cases, the spiked beverages are the “crime weapons”.

In this paper, it will be presented the relation of drug facilitated crimes and the toxicology science and also a review focused on the available analytical methods for the detection of adulterated beverages with drugs. 

References

Flanagan RJ, Taylor AA, Watson ID, Whelpton R. Fundamentals of Analytical Toxicology. En- gland: John Wiley & Sons Ltd; 2008.

Couchman L, Morgan PE. LC-MS in analytical toxi- cology: some practical considerations. Biomed Chromatogr. 2011; 25(1-2):100-23.

Moffat A, Osselton M, Widdop B, Jickells S, Ne- grusz A. Introduction to forensic toxicology. In: Jickells S, Negrusz A, editors. Clarke’s Analyti- cal Forensic Toxicology. 1st ed: Pharmaceutical Press; 2008. p. 1-11.

Goldberger BA, Polettini A. Forensic toxicology: web resources. Toxicology. 2002; 173(1-2):97-102. 5. Kintz P. Bioanalytical procedures for detection of chemical agents in hair in the case of drug- -facilitated crimes. Anal Bioanal Chem. 2007;

(7):1467-74.

(SOFT) SoFT. Drug-Facilitated Sexual Assault

Committee. Recommended Maximum De- tection Limits for Common DFSA Drugs and Metabolites in Urine Samples 2005 [updated 26/09/2013]. Available from: http://www.soft- -tox.org/files/SOFT-DFSA-List.pdf.

Fernando R. Homicidal poisoning with gliben- clamide. Med Sci Law. 1999; 39(4):354-8.

LeBeau M, Andollo W, Hearn WL, Baselt R, Cone E, Finkle B, et al. Recommendations for toxico- logical investigations of drug-facilitated sexual assaults. J Forensic Sci. 1999; 44(1):227-30.

LeBeau MA. Guidance for improved detection of drugs used to facilitate crimes. Ther Drug Monit. 2008; 30(2):229-33.

Dorandeu AH, Pages CA, Sordino M-C, Pepin G, Baccino E, Kintz P. A case in south-eastern Fran- ce: a review of drug facilitated sexual assault in European and English-speaking countries. J Clin Forensic Med. 2006; 13(5):253-61.

Papadodima SA, Athanaselis SA, Spiliopoulou C. Toxicological investigation of drug-facilita- ted sexual assaults. Int J Clin Practice. 2007; 61(2):259-64.

Gallardo E, Queiroz JA. The role of alternative specimens in toxicological analysis. Biomed Chromatogr. 2008; 22(8):795-821.

Beynon CM, Sumnall HR, McVeigh J, Cole JC, Bellis MA. The ability of two commercially avai- lable quick test kits to detect drug-facilitated sexual assault drugs in beverages. Addiction. 2006; 101(10):1413-20.

Brown SD, Melton TC. Trends in bioanalytical methods for the determination and quantification of club drugs: 2000-2010. Biomed Chromatogr. 2011; 25(1-2):300-21.

Uges D, Hallworth M, Moore C, Negrusz A. Cli-

nical toxicology, therapeutic drug monitoring, in utero exposure to drugs of abuse. In: Jickells S, Negrusz A, editors. Clarke’s Analytical Foren- sic Toxicology. 1st ed. England: Pharmaceutical Press; 2008. p. 219-60.

Sarin RK, Sharma GP, Varshney KM, Rasool SN. Determination of diazepam in cold drinks by high-performance thin-layer chromatography. J Chromatogr A. 1998; 822(2):332-5.

Chen Y-C, Hu A. Simultaneous determination of trace benzodiazepines from drinks by using direct electrospray probe/mass spectrometry (DEP/MS). Forensic Sci Int. 1999; 103(2):79-88.

Rao RN, Parimala P, Khalid S, Alvi SN. Detection of the adulteration of traditional alcoholic be- verages by the separation and determination of alprazolam, chloralhydrate and diazepam using reversed-phase high-performance liquid chro- matography. Anal Sci. 2004; 20(2):383-6.

Bishop SC, Lerch M, McCord BR. Micellar elec- trokinetic chromatographic screening method for common sexual assault drugs administered in beverages. Forensic Sci Int. 2004; 141(1):7- 15.

Olsen V, Gustavsen I, Bramness JG, Hasvold I, Karinen R, Christophersen AS, et al. The con- centrations, appearance and taste of nine seda- ting drugs dissolved in four different beverages. Forensic Sci Int. 2005; 151(2-3):171-5.

Elliott S, Burgess V. The presence of gamma- -hydroxybutyric acid (GHB) and gamma-butyro- lactone (GBL) in alcoholic and non-alcoholic be- verages. Forensic Sci Int. 2005; 151(2-3):289-92.

Meyers JE, Almirall JR. Analysis of gamma-hydro- xybutyric acid (GHB) in spiked water and beve- rage samples using solid phase microextraction (SPME) on fiber derivatization/gas chromato- graphy-mass spectrometry (GC/MS). J Forensic Sci. 2005; 50(1):31-6.

Grootveld M, Algeo D, Silwood CJL, Blackburn JC, Clark AD. Determination of the illicit drug gamma-hydroxybutyrate (GHB) in human saliva and beverages by H-1 NMR analysis. Biofac-

tors. 2006; 27(1-4):121-36.

Bishop SC, Lerch M, McCord BR. Detection of

nitrated benzodiazepines by indirect laser-in- duced fluorescence detection on a microfluidic device. J Chromatogr A. 2007; 1154(1-2):481-4.

Webb R, Doble P, Dawson M. A rapid CZE method for the analysis of benzodiazepines in spiked beverages. Electrophoresis. 2007; 28(19):3553-65.

Honeychurch KC, Hart JP. Determination of flunitrazepam and nitrazepam in beverage samples by liquid chromatography with dual electrode detection using a carbon fibre veil electrode. J Solid State Electrochem. 2008; 12(10):1317-24.

Acikkol M, Mercan S, Karadayi S. Simultaneous Determination of Benzodiazepines and Ketami- ne from Alcoholic and Nonalcoholic Beverages by GC-MS in Drug Facilitated Crimes. Chroma- tographia. 2009; 70(7-8):1295-8.

Lesar CT, Decatur J, Lukasiewicz E, Champeil E. Report on the analysis of common beverages spiked with gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) using NMR and the PURGE solvent-suppression technique. Forensic Sci Int. 2011; 212(1-3):E40-E5.

D’AloiseP,ChenH.Rapiddeterminationofflu- nitrazepam in alcoholic beverages by desorp- tion electrospray ionization-mass spectrometry. Science & Justice. 2012; 52(1):2-8.

Sáiz J, Mai TD, López ML, Bartolomé C, Hauser PC, García-Ruiz C. Rapid determination of sco- polamine in evidence of recreational and pre- datory use. Science & Justice. 2013.

Calatayud JM. Flow Injection Analysis of Phar- maceuticals: Automation in the Laboratory. 1st ed. London: Taylor & Francis in Pharmaceutical Sciences; 1996.

Lapa RAS, Lima J, Reis BF, Santos JLM, Zagatto EAG. Multi-pumping in flow analysis: concepts, instrumentation, potentialities. Anal Chim Acta. 2002; 466(1):125-32.

Ribeiro DSM, Prior JAV, Santos JLM, Lima JLFC. Automated determination of diazepam inspiked alcoholic beverages associated with drug-facilitated crimes. Anal Chim Acta. 2010; 668(1):67-73.

Ribeiro DSM, Prior JAV, Taveira CJM, Mendes JMAFS, Santos JLM. Automatic miniaturized fluorometric flow system for chemical and to- xicological control of glibenclamide. Talanta. 2011; 84(5):1329-35.

Ribeiro DSM, Lopes JA, Santos JLM, Prior JAV. Exploiting adsorption and desorption at solid– liquid interface for the fluorometric monitoring of glibenclamide in adulterated drinks. Anal Chim Acta. 2012; 721:97-103.

Section
Artigos