CANINE VISCERAL LEISHMANIASIS (CVL): integrative review of the literature on case reports of treatment with Miltefosine

Abstract

Canine visceral leishmaniasis (CVL) is a serious parasitic disease, caused by the protozoan Leishmania spp, which represents a significant public health problem in several regions of the world, including Brazil. This course conclusion work has as its theme the integrative review of the literature on case reports of CVL treatment with Miltefosine, a medication that has shown promise in the therapy of the disease. There is a perceived need to gather and critically analyze the case reports available in the scientific literature on the use of Miltefosine, aiming to comprehensively understand the results obtained with this therapy. Analysis of available evidence will identify gaps in knowledge and encourage the carrying out of new controlled and randomized clinical studies. Therefore, the objective of this research was to prepare an integrative review of the literature on case studies of dogs affected by CVL and who were treated with Miltefosine, presenting the treatment and prognoses. The material was collected on the Google Scholar and Bvs platform in articles and course completion works published between 2019 and 2024. The conclusions of the study indicate that Miltefosine demonstrated efficacy in reducing the parasitic load in dogs affected by CVL, contributing to the improvement prognosis and quality of life of treated animals.

Keywords: Canine Visceral Leishmaniasis, CVL, veterinary treatment, public health, Milteforan®.