Procedimentos Operativos Normalizados para pesquisa de informação clínica sobre reações adversas no contexto da infeção VIH/SIDA

C. Abrantes; A. C. Rama; M. M. Caramona; A. Meliço-Silvestre; F. Fernandez-Llimos; I. V. Figueiredo

C. Abrantes Grupo de Farmacologia e Cuidados Farmacêuticos, Faculdade de Farmácia, Universidade de Coimbra, Portugal. Centro de Estudos Farmacêuticos (CEF), Faculdade de Farmácia, Universidade de Coimbra, Portugal.
A. C. Rama Grupo de Farmacologia e Cuidados Farmacêuticos, Faculdade de Farmácia, Universidade de Coimbra, Portugal. Centro de Estudos Farmacêuticos (CEF), Faculdade de Farmácia, Universidade de Coimbra, Portugal. Serviços Farmacêuticos, Hospitais da Universidade de Coimbra, Portugal.
M. M. Caramona Grupo de Farmacologia e Cuidados Farmacêuticos, Faculdade de Farmácia, Universidade de Coimbra, Portugal. Centro de Estudos Farmacêuticos (CEF), Faculdade de Farmácia, Universidade de Coimbra, Portugal.
A. Meliço-Silvestre Faculdade de Medicina, Universidade de Coimbra, Portugal.
F. Fernandez-Llimos Departamento de Sócio-Farmácia, Faculdade de Farmácia, Universidade de Lisboa, Portugal. Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculdade de Farmácia, Universidade de Lisboa, Portugal.
I. V. Figueiredo Grupo de Farmacologia e Cuidados Farmacêuticos, Faculdade de Farmácia, Universidade de Coimbra, Portugal. Centro de Estudos Farmacêuticos (CEF), Faculdade de Farmácia, Universidade de Coimbra, Portugal.

Keywords: Human Immunodeficiency Virus (HIV), Acquired Immunodeficiency Syndrome (AIDS), Highly active antiretroviral therapy (HAART), Adverse Effects, Evidence Based Medicine.

Abstract

Information related to adverse effects of antiretroviral therapy can determine non-compliance and future therapeutic options.

Evidence based practice includes a focalized clinical question to obtain the better information assessed by the parameters sensitivity and specificity.

The main purpose of the work is the optimization of a systematic methodology of research clinical information about adverse effects of antiretroviral therapy, in MEDLINE database, with their identification in the literature and the construction of different search strategies to subsequent comparison of sensitivity and specificity values. A generic search strategy developed to find information related to drug iatrogenicity was considered as a reference to the development of search studied strategies.

The results show the known adverse effects of antiretroviral agents that are mainly found in case reports.

As the first work that approaches two different concepts simultaneously, adverse effects of antiretro-viral therapy and evidence based medicine approach to search literature, it shows and reinforces the real need for more available information to a better assessment of its quality.

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