Evidence on the biomodulatory potential of oral collagen peptide supplementation for skin aging: composition, mechanism of action, bioavailability, eficacy and toxicity

  • Lucas Lima
  • Thalita Quintal
  • Thainá Soares
  • Caroline Ribeiro
  • Lara Silva
  • Evenny Lima
  • Láila Vieira
  • Antony Barbosa


Dietary and nutraceutical supplements based on hydrolyzed collagen are capable of modulating the biomechanical and functional properties of the skin tissue. Hydrolyzed collagen (CH) is a group of low molecular weight (3-6 KDa) peptides that can be obtained through the enzymatic hydrolysis of native collagen derived from animal (commonly bovine, porcine or marine) or vegetable sources. The stimulation of the synthesis of structural elements of the dermis has been proposed as one of the main factors associated with its promising biological effects however, its cellular and molecular mechanisms are still unknown in the literature. Thus, this literature review summarizes the most relevant clinical and experimental scientific studies on the composition, action mechanisms, absorption, bioavailability, effectiveness, toxicity and its therapeutic potential response on dermal aging.