O Sistema Endocanabinóide – uma perspetiva terapêutica

B.M. Fonseca, M.A. Costa, M. Almada, A. Soares, G. Correia-da-Silva, Natércia A. Teixeira

Resumo


A utilização terapêutica da Cannabis sativa ou seus derivados é conhecida há muitos anos, no entanto, o estudo das suas propriedades despontou recentemente com a descoberta de um sistema canabinóide endógeno (ECS). O ECS compreende os compostos endógenos similares ao tetrahidrocanabinol (endocanabinóides), os recetores canabinóides (CB1 e CB2) e as enzimas envolvidas no seu metabolismo. Desde a descoberta do ECS, a comunidade científica focou-se na investigação do seu potencial clínico com resultados encorajadores. Em alguns países, os derivados da cannabis constituem uma opção farmacológica na estimulação do apetite e tratamento da dor. O primeiro medicamento baseado no ECS, o rimonabant (um antagonista CB1), foi aprovado para o tratamento da obesidade associada a outros fatores de risco, no entanto foi retirado por questões de segurança. Atualmente, e baseadas nos estudos pré-clínicos e clínicos, existem várias evidências do seu interesse clínico na modulação de diversas condições fisiopatológicas. Neste artigo discutimos o papel potencial do sistema (endo)canabinóide na terapêutica e as recentes estratégias desenvolvidas na modulação do sistema. 


Palavras-chave


Endocanabinóides; Recetores canabinóides; Farmacoterapia

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Acta Farmacêutica Portuguesa - ISSN: 2182-3340